{"id":31840,"date":"2021-03-18T14:04:14","date_gmt":"2021-03-18T13:04:14","guid":{"rendered":"https:\/\/www.kasiterit.eu\/?p=31840"},"modified":"2022-01-14T19:12:28","modified_gmt":"2022-01-14T18:12:28","slug":"multi-liekova-rezistencia-mdr1","status":"publish","type":"post","link":"https:\/\/www.kasiterit.eu\/en\/multi-liekova-rezistencia-mdr1\/","title":{"rendered":"Multi liekov\u00e1 rezistencia MDR1"},"content":{"rendered":"\t\t
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\n\t\t\t\t\t\t\t\t\tMDR1 = Multi drug resistance 1 = Multi liekov\u00e1 rezistencia<\/b>\n\nPre ka\u017ed\u00e9ho majite\u013ea Bearded collie a\u00a0OES\/Bobtaila je d\u00f4le\u017eit\u00e9 vedie\u0165 o\u00a0tejto genetickej mut\u00e1cii, ktor\u00e1 m\u00f4\u017ee ohrozi\u0165 \u017eivot jeho ps\u00edka, dokonca m\u00f4\u017ee sp\u00f4sobi\u0165 jeho smr\u0165.\n\nMDR1 je g\u00e9n naz\u00fdvan\u00fd multi liekov\u00e1 rezistencia. Mut\u00e1cia tohto g\u00e9nu sp\u00f4sobuje citlivos\u0165 na Ivermekt\u00edn a \u010fal\u0161ie lieky. Psi s\u00a0touto mut\u00e1ciou reaguj\u00fa citlivo na podanie t\u00fdchto liekov. Intenzita reakcie z\u00e1vis\u00ed od d\u00e1vky lieku. N\u00edzke d\u00e1vky lieku, ktor\u00e9 s\u00fa pou\u017eit\u00e9 napr. v\u00a0pr\u00edpravkoch proti srdcov\u00fdm \u010dervom nemusia vyvola\u0165 negat\u00edvnu reakciu. Typick\u00e9 d\u00e1vky a\u00a0a\u00a0r\u00f4znorodos\u0165 liekov sp\u00f4sobia reakciu u\u00a0psov s\u00a0dvoma k\u00f3piami mut\u00e1cie, ale niektor\u00e9 lieky \u2013 naj\u010dastej\u0161ie niektor\u00e9 chemoterapeutik\u00e1 \u2013m\u00f4\u017eu sp\u00f4sobi\u0165 reakciu aj u\u00a0psov s\u00a0jednou k\u00f3piou mut\u00e1cie.\n
Psi \u2013 nositelia tohto g\u00e9nu m\u00f4\u017eu po podan\u00ed liekov (naspodu v\u00a0zozname) trpie\u0165\u00a0 <\/span>v\u00e1\u017enymi neurologick\u00fdmi pr\u00edznakmi, z\u00e1chvatmi a\u00a0niekedy nasleduje aj smr\u0165.<\/blockquote>\nGenetick\u00e1 mut\u00e1cia MDR1 je dedi\u010dn\u00e1.\n\nJe mo\u017en\u00e9 necha\u0165 svojho ps\u00edka geneticky vy\u0161etri\u0165. Netreba odber krvi, sta\u010d\u00ed v\u00fdter sl\u00edn. Vy\u0161etren\u00edm DNA svojho ps\u00edka viete, \u010di nemus\u00edte ma\u0165 strach alebo \u010di treba by\u0165 v\u00a0strehu a\u00a0hlavne, \u010di treba o\u00a0tom informova\u0165 o\u0161etruj\u00faceho veterin\u00e1rneho lek\u00e1ra!\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tStiahnu\u0165 let\u00e1k pdf<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tZoznam liekov pdf<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

MDR1 = Multi drug resistance 1 = Multi liekov\u00e1 rezistencia Pre ka\u017ed\u00e9ho majite\u013ea Bearded collie a OES\/Bobtaila je d\u00f4le\u017eit\u00e9 vedie\u0165 o tejto genetickej mut\u00e1cii, ktor\u00e1 m\u00f4\u017ee ohrozi\u0165 \u017eivot jeho ps\u00edka, dokonca m\u00f4\u017ee sp\u00f4sobi\u0165 jeho smr\u0165. MDR1 je g\u00e9n naz\u00fdvan\u00fd multi liekov\u00e1 rezistencia. Mut\u00e1cia tohto g\u00e9nu sp\u00f4sobuje citlivos\u0165 na Ivermekt\u00edn a \u010fal\u0161ie lieky. Psi s touto mut\u00e1ciou reaguj\u00fa citlivo […]<\/p>\n","protected":false},"author":1,"featured_media":35414,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-31840","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-novinky"],"_links":{"self":[{"href":"https:\/\/www.kasiterit.eu\/en\/wp-json\/wp\/v2\/posts\/31840","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.kasiterit.eu\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.kasiterit.eu\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.kasiterit.eu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kasiterit.eu\/en\/wp-json\/wp\/v2\/comments?post=31840"}],"version-history":[{"count":0,"href":"https:\/\/www.kasiterit.eu\/en\/wp-json\/wp\/v2\/posts\/31840\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.kasiterit.eu\/en\/wp-json\/wp\/v2\/media\/35414"}],"wp:attachment":[{"href":"https:\/\/www.kasiterit.eu\/en\/wp-json\/wp\/v2\/media?parent=31840"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.kasiterit.eu\/en\/wp-json\/wp\/v2\/categories?post=31840"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.kasiterit.eu\/en\/wp-json\/wp\/v2\/tags?post=31840"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}